Posts in Category ‘News

Announcement of MDSGene

Investigators from LIGA and the Institute of Neurogenetics today announced their upcoming launch of MDSGene, the Movement Disorders Society Genetics database. MDSGene aims to provide a comprehensive, systematic overview of published data on movement disorder patients reported to carry causative gene mutations. The official launch of the resource will happen during the 20th Congress of the International Movement Disorders Society which takes place in Berlin between June 19-23. After AlzGene, ALSGene, and PDGene, MDSGene (which will become available at www.mdsgene.org) represents the fourth genetics database developed by the LIGA team. The launch announcement was published as an editorial by members of the MDSGene team in the journal Movement Disorders.

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Study on 400,000 individuals finds genes for educational attainment

This study is the second effort coordinated by the Social Science Genetics Association Consortium (SSGAC) to which LIGA contributed data from the Berlin Aging Study II. This newest analysis employed a genome-wide association study (GWAS) approach in 300,000 persons searching for genetic determinants of educational achievement, the largest-ever genetics study in the social sciences. A total of 74 loci were revealed to show genome-wide significant association with years of schooling. The identified loci were enriched for genomic regions regulating gene expression in the fetal brain. The study was published in the journal Nature.

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Novel guidelines for preclinical Alzheimer’s disease

Our group has participated in a recent effort to formulate novel recommendations about the definitions, the limits, the natural history, the markers of progression, and the ethical consequence of detecting Alzheimer’s disease at its preclinical, asymptomatic stage. This work is the result of a workshop held by the International Working Group (IWG) and the American Alzheimer’s Association on “The Preclinical State of AD” on July 23, 2015; Washington DC, USA. The guidelines were recently published in the journal Alzheimer’s & Dementia.

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