Publications

2019

Jessica Schulz, Petros Takousis, Inken Wohlers, Ivie Itua, Valerija Dobricic, Harald Binder, Lefkos Middleton, John Ioannidis, Robert Perneczky, Lars Bertram, Christina Lill (in press) Systematic meta-analyses identify differentially expressed microRNAs in Parkinson's disease. Ann Neurol (in press). Preprint available at: 10.1101/253849

Karasik, D, Zillikens, MC, Hsu, YH, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, DA, Bertram, L, Bochud, M, Borecki, IB, Broer, L, Buchman, AS, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, JA, Cawthon, PM, Chambers, JC, Chen, Z et al. (2019) Disentangling the genetics of lean mass.. Am. J. Clin. Nutr. 109 (2):276-287. doi: 10.1093/ajcn/nqy272 PubMed PMID:30721968

Karlsson Linnér, R, Biroli, P, Kong, E, Meddens, SFW, Wedow, R, Fontana, MA, Lebreton, M, Tino, SP, Abdellaoui, A, Hammerschlag, AR, Nivard, MG, Okbay, A, Rietveld, CA, Timshel, PN, Trzaskowski, M, Vlaming, R, Zünd, CL, Bao, Y, Buzdugan, L, Caplin, AH et al. (2019) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.. Nat. Genet. 51 (2):245-257. doi: 10.1038/s41588-018-0309-3 PubMed PMID:30643258

Trinh, J, Lohmann, K, Baumann, H, Balck, A, Borsche, M, Brüggemann, N, Dure, L, Dean, M, Volkmann, J, Tunc, S, Prasuhn, J, Pawlack, H, Imhoff, S, Lill, CM, Kasten, M, Bauer, P, Rolfs, A, International Parkinson's Disease Genomics Consortium (IPDGC), Klein, C (2019) Utility and implications of exome sequencing in early-onset Parkinson's disease.. Mov. Disord. 34 (1):133-137. doi: 10.1002/mds.27559 PubMed PMID:30537300

 

2018

Petros Takousis, Angélique Sadlon, Jessica Schulz, Inken Wohlers, Valerija Dobricic, Lefkos Middleton, Christina M. Lill, Robert Perneczky, Lars Bertram (2018) Differential expression of microRNAs in Alzheimer's disease brain, blood and cerebrospinal fluid: a systematic review and meta-analysis. bioRxiv 499491; doi: 10.1101/499491

Inken Wohlers, Colin Schulz, Fabian Kilpert, Lars Bertram (2018) Alzheimer's disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines. bioRxiv 367318; doi: 10.1101/367318

Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S Fleur W Meddens, Robbee Wedow, Mark Alan Fontana, Maël Lebreton, Abdel Abdellaoui, Anke R Hammerschlag, Michel G Nivard, Aysu Okbay, et al. (2018) Genome-wide study identifies 611 loci associated with risk tolerance and risky behaviors. bioRxiv 261081; doi: 10.1101/176511

Trinh, J, Lohmann, K, Baumann, H, Balck, A, Borsche, M, Brüggemann, N, Dure, L, Dean, M, Volkmann, J, Tunc, S, Prasuhn, J, Pawlack, H, Imhoff, S, Lill, CM, Kasten, M, Bauer, P, Rolfs, A, International Parkinson's Disease Genomics Consortium (IPDGC), Klein, C (2019) Utility and implications of exome sequencing in early-onset Parkinson's disease.. Mov. Disord. 34 (1):133-137. doi: 10.1002/mds.27559 PubMed PMID:30537300

Reinthaler, EM, Graf, E, Zrzavy, T, Wieland, T, Hotzy, C, Kopecky, C, Pferschy, S, Schmied, C, Leutmezer, F, Keilani, M, Lill, CM, Hoffjan, S, Epplen, JT, Zettl, UK, Hecker, M, Deutschländer, A, Meuth, SG, Ahram, M, Mustafa, B, El-Khateeb, M et al. (2018) TPP2 mutation associated with sterile brain inflammation mimicking MS.. Neurol Genet. 4 (6):e285. doi: 10.1212/NXG.0000000000000285 PubMed PMID:30533531

Trinh, J, Zeldenrust, FMJ, Huang, J, Kasten, M, Schaake, S, Petkovic, S, Madoev, H, Grünewald, A, Almuammar, S, König, IR, Lill, CM, Lohmann, K, Klein, C, Marras, C (2018) Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.. Mov. Disord. 33 (12):1857-1870. doi: 10.1002/mds.27527 PubMed PMID:30357936

Herwest, S, Albers, C, Schmiester, M, Salewsky, B, Hopfenmüller, W, Meyer, A, Bertram, L, Demuth, I (2018) The hSNM1B/Apollo variant rs11552449 is associated with cellular sensitivity towards mitomycin C and ionizing radiation.. DNA Repair (Amst.). 72 :93-98. doi: 10.1016/j.dnarep.2018.09.004 PubMed PMID:30262195

Ten Kate, M, Redolfi, A, Peira, E, Bos, I, Vos, SJ, Vandenberghe, R, Gabel, S, Schaeverbeke, J, Scheltens, P, Blin, O, Richardson, JC, Bordet, R, Wallin, A, Eckerstrom, C, Molinuevo, JL, Engelborghs, S, Van Broeckhoven, C, Martinez-Lage, P, Popp, J, Tsolaki, M et al. (2018) MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study.. Alzheimers Res Ther. 10 (1):100. doi: 10.1186/s13195-018-0428-1 PubMed PMID:30261928

Wohlers, I, Bertram, L (2018) Taking genomics research to the next level: The Genotype-Tissue expression project.. Mov. Disord. 33 (7):1097. doi: 10.1002/mds.27445 PubMed PMID:30153387

Wohlers, I, Bertram, L, Lill, CM (2018) Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics.. J. Autoimmun. 94 :83-89. doi: 10.1016/j.jaut.2018.07.010 PubMed PMID:30143393

Ohlei, O, Dobricic, V, Lohmann, K, Klein, C, Lill, CM, Bertram, L (2018) Field synopsis and systematic meta-analyses of genetic association studies in isolated dystonia.. Parkinsonism Relat. Disord. 57 :50-57. doi: 10.1016/j.parkreldis.2018.07.018 PubMed PMID:30100364

Lee, JJ, Wedow, R, Okbay, A, Kong, E, Maghzian, O, Zacher, M, Nguyen-Viet, TA, Bowers, P, Sidorenko, J, Karlsson Linnér, R, Fontana, MA, Kundu, T, Lee, C, Li, H, Li, R, Royer, R, Timshel, PN, Walters, RK, Willoughby, EA, Yengo, L et al. (2018) Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.. Nat. Genet. 50 (8):1112-1121. doi: 10.1038/s41588-018-0147-3 PubMed PMID:30038396

Bos, I, Vos, S, Vandenberghe, R, Scheltens, P, Engelborghs, S, Frisoni, G, Molinuevo, JL, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Baird, A, Dobson, R, Legido-Quigley, C, Sleegers, K, Van Broeckhoven, C, Bertram, L, Ten Kate, M, Barkhof, F, Zetterberg, H et al. (2018) The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.. Alzheimers Res Ther. 10 (1):64. doi: 10.1186/s13195-018-0396-5 PubMed PMID:29980228

Davies, G, Lam, M, Harris, SE, Trampush, JW, Luciano, M, Hill, WD, Hagenaars, SP, Ritchie, SJ, Marioni, RE, Fawns-Ritchie, C, Liewald, DCM, Okely, JA, Ahola-Olli, AV, Barnes, CLK, Bertram, L, Bis, JC, Burdick, KE, Christoforou, A, DeRosse, P, Djurovic, S et al. (2018) Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nat Commun. 9 (1):2098. doi: 10.1038/s41467-018-04362-x PubMed PMID:29844566

Kasten, M, Hartmann, C, Hampf, J, Schaake, S, Westenberger, A, Vollstedt, EJ, Balck, A, Domingo, A, Vulinovic, F, Dulovic, M, Zorn, I, Madoev, H, Zehnle, H, Lembeck, CM, Schawe, L, Reginold, J, Huang, J, König, IR, Bertram, L, Marras, C et al. (2018) Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review.. Mov. Disord. 33 (5):730-741. doi: 10.1002/mds.27352 PubMed PMID:29644727

Graetz, C, Gröger, A, Luessi, F, Salmen, A, Zöller, D, Schultz, J, Siller, N, Fleischer, V, Bellenberg, B, Berthele, A, Biberacher, V, Havla, J, Hecker, M, Hohlfeld, R, Infante-Duarte, C, Kirschke, JS, Kümpfel, T, Linker, R, Paul, F, Pfeuffer, S et al. (2018) Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.. Mult. Scler. :1352458518763541. doi: 10.1177/1352458518763541 PubMed PMID:29532745

Walhovd, KB, Fjell, AM, Westerhausen, R, Nyberg, L, Ebmeier, KP, Lindenberger, U, Bartrés-Faz, D, Baaré, WFC, Siebner, HR, Henson, R, Drevon, CA, Strømstad Knudsen, GP, Ljøsne, IB, Penninx, BWJH, Ghisletta, P, Rogeberg, O, Tyler, L, Bertram, L, Lifebrain Consortium (2018) Healthy minds 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain").. Eur. Psychiatry. 50 :47-56. doi: 10.1016/j.eurpsy.2017.12.006 PubMed PMID:29449073

Paul, KC, Schulz, J, Bronstein, JM, Lill, CM, Ritz, BR (2018) Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.. JAMA Neurol. 75 (3):360-366. doi: 10.1001/jamaneurol.2017.4206 PubMed PMID:29340614

Schuck, NW, Petok, JR, Meeter, M, Schjeide, BM, Schröder, J, Bertram, L, Gluck, MA, Li, SC (2018) Aging and a genetic KIBRA polymorphism interactively affect feedback- and observation-based probabilistic classification learning.. Neurobiol. Aging. 61 :36-43. doi: 10.1016/j.neurobiolaging.2017.08.026 PubMed PMID:29032191

 

2017

Gail Davies, Max Lam, Sarah E. Harris, Joey Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloë Fawns-Ritchie, David C. Liewald, Judith Okely, Ari Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, et al. (2017) Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360). bioRxiv 176511; doi: 10.1101/176511

Walhovd, KB, Fjell, AM, Westerhausen, R, Nyberg, L, Ebmeier, KP, Lindenberger, U, Bartrés-Faz, D, Baaré, WFC, Siebner, HR, Henson, R, Drevon, CA, Knudsen, GP, Budin-Ljøsne, I, Penninx, BWJH, Ghisletta, P, Rogeberg, O, Tyler, L, Bertram, L, for Lifebrain Consortium (2017) Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain").. Eur. Psychiatry. 47 :76-87. doi: 10.1016/j.eurpsy.2017.10.005 PubMed PMID:29127911

Zillikens, MC, Demissie, S, Hsu, YH, Yerges-Armstrong, LM, Chou, WC, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A et al. (2017) Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.. Nat Commun. 8 (1):1414. doi: 10.1038/s41467-017-01008-2 PubMed PMID:29116125

Schuck, NW, Petok, JR, Meeter, M, Schjeide, BM, Schröder, J, Bertram, L, Gluck, MA, Li, SC (2018) Aging and a genetic KIBRA polymorphism interactively affect feedback- and observation-based probabilistic classification learning.. Neurobiol. Aging. 61 :36-43. doi: 10.1016/j.neurobiolaging.2017.08.026 PubMed PMID:29032191

Joshi, PK, Pirastu, N, Kentistou, KA, Fischer, K, Hofer, E, Schraut, KE, Clark, DW, Nutile, T, Barnes, CLK, Timmers, PRHJ, Shen, X, Gandin, I, McDaid, AF, Hansen, TF, Gordon, SD, Giulianini, F, Boutin, TS, Abdellaoui, A, Zhao, W, Medina-Gomez, C et al. (2017) Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.. Nat Commun. 8 (1):910. doi: 10.1038/s41467-017-00934-5 PubMed PMID:29030599

Chuang, YH, Lee, PC, Vlaar, T, Mulot, C, Loriot, MA, Hansen, J, Lill, CM, Ritz, B, Elbaz, A (2017) Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease.. Ann. Neurol. 82 (5):655-664. doi: 10.1002/ana.25065 PubMed PMID:28981958

Buchmann, N, Scholz, M, Lill, CM, Burkhardt, R, Eckardt, R, Norman, K, Loeffler, M, Bertram, L, Thiery, J, Steinhagen-Thiessen, E, Demuth, I (2017) Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin.. Acta Diabetol. 54 (11):1031-1038. doi: 10.1007/s00592-017-1036-4 PubMed PMID:28866807

Lill, CM, Klein, C (2017) What would Dr. James Parkinson think today? The role of genetics in Parkinson's disease.. Mov. Disord. 32 (8):1115-1116. doi: 10.1002/mds.27141 PubMed PMID:28836355

Zillikens, MC, Demissie, S, Hsu, YH, Yerges-Armstrong, LM, Chou, WC, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A et al. (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.. Nat Commun. 8 (1):80. doi: 10.1038/s41467-017-00031-7 PubMed PMID:28724990

Zenk, F, Loeser, E, Schiavo, R, Kilpert, F, Bogdanović, O, Iovino, N (2017) Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition.. Science. 357 (6347):212-216. doi: 10.1126/science.aam5339 PubMed PMID:28706074

Marras, C, Lang, A, van de Warrenburg, BP, Sue, CM, Tabrizi, SJ, Bertram, L, Mercimek-Mahmutoglu, S, Ebrahimi-Fakhari, D, Warner, TT, Durr, A, Assmann, B, Lohmann, K, Kostic, V, Klein, C (2017) Nomenclature of genetic movement disorders: Recommendations of the International Parkinson and Movement Disorder Society task force.. Mov. Disord. 32 (5):724-725. doi: 10.1002/mds.27045 PubMed PMID:28513081

Lill, CM, Klein, C (2017) [Epidemiology and causes of Parkinson's disease].. Nervenarzt. 88 (4):345-355. doi: 10.1007/s00115-017-0288-0 PubMed PMID:28289797

Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-Hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.. Lancet Diabetes Endocrinol. 5 (2):97-105. doi: 10.1016/S2213-8587(16)30396-5 PubMed PMID:27908689

 

2016

Chuang, YH, Lill, CM, Lee, PC, Hansen, J, Lassen, CF, Bertram, L, Greene, N, Sinsheimer, JS, Ritz, B (2016) Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2.. Neuroepidemiology. 47 (3-4):192-200. doi: 10.1159/000450855 PubMed PMID:28135712

Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-Hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.. Lancet Diabetes Endocrinol. 5 (2):97-105. doi: 10.1016/S2213-8587(16)30396-5 PubMed PMID:27908689

Lill, CM (2016) Genetics of Parkinson's disease.. Mol. Cell. Probes. 30 (6):386-396. doi: 10.1016/j.mcp.2016.11.001 PubMed PMID:27818248

Biernacka, JM, Chung, SJ, Armasu, SM, Anderson, KS, Lill, CM, Bertram, L, Ahlskog, JE, Brighina, L, Frigerio, R, Maraganore, DM (2016) Genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease.. Parkinsonism Relat. Disord. 32 :25-30. doi: 10.1016/j.parkreldis.2016.08.002 PubMed PMID:27545685

Marioni, RE, Ritchie, SJ, Joshi, PK, Hagenaars, SP, Okbay, A, Fischer, K, Adams, MJ, Hill, WD, Davies, G, Social Science Genetic Association Consortium, Nagy, R, Amador, C, Läll, K, Metspalu, A, Liewald, DC, Campbell, A, Wilson, JF, Hayward, C, Esko, T, Porteous, DJ et al. (2016) Genetic variants linked to education predict longevity.. Proc. Natl. Acad. Sci. U.S.A. 113 (47):13366-13371. doi: 10.1073/pnas.1605334113 PubMed PMID:27799538

Barban, N, Jansen, R, de Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Tragante, V, van der Laan, SW, Perry, JR, Kong, A, BIOS Consortium, Ahluwalia, TS, Albrecht, E, Yerges-Armstrong, L, Atzmon, G, Auro, K et al. (2016) Genome-wide analysis identifies 12 loci influencing human reproductive behavior.. Nat. Genet. 48 (12):1462-1472. doi: 10.1038/ng.3698 PubMed PMID:27798627

Lee, PC, Raaschou-Nielsen, O, Lill, CM, Bertram, L, Sinsheimer, JS, Hansen, J, Ritz, B (2016) Gene-environment interactions linking air pollution and inflammation in Parkinson's disease.. Environ. Res. 151 :713-720. doi: 10.1016/j.envres.2016.09.006 PubMed PMID:27640071

Herold, C, Hooli, BV, Mullin, K, Liu, T, Roehr, JT, Mattheisen, M, Parrado, AR, Bertram, L, Lange, C, Tanzi, RE (2016) Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.. Mol. Psychiatry. 21 (11):1608-1612. doi: 10.1038/mp.2015.218 PubMed PMID:26830138

Klein, C, Lang, A, van de Warrenburg, BP, Sue, CM, Tabrizi, SJ, Bertram, L, Mercimek-Mahmutoglu, S, Ebrahimi-Fakhari, D, Warner, TT, Durr, A, Assmann, B, Kostic, V, Lohmann, K, Marras, C, International Parkinson and Movement Disorder Society Task Force on Classification and Nomenclature of Genetic Movement Disorders (2016) Reply letter to Jinnah "Locus pocus" and Albanese "Complex dystonia is not a category in the new 2013 consensus classification": Necessary evolution, no magic!. Mov. Disord. 31 (11):1760-1762. doi: 10.1002/mds.26763 PubMed PMID:27619077

Andlauer, TF, Buck, D, Antony, G, Bayas, A, Bechmann, L, Berthele, A, Chan, A, Gasperi, C, Gold, R, Graetz, C, Haas, J, Hecker, M, Infante-Duarte, C, Knop, M, Kümpfel, T, Limmroth, V, Linker, RA, Loleit, V, Luessi, F, Meuth, SG et al. (2016) Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.. Sci Adv. 2 (6):e1501678. doi: 10.1126/sciadv.1501678 PubMed PMID:27386562

Okbay, A, Beauchamp, JP, Fontana, MA, Lee, JJ, Pers, TH, Rietveld, CA, Turley, P, Chen, GB, Emilsson, V, Meddens, SF, Oskarsson, S, Pickrell, JK, Thom, K, Timshel, P, de Vlaming, R, Abdellaoui, A, Ahluwalia, TS, Bacelis, J, Baumbach, C, Bjornsdottir, G et al. (2016) Genome-wide association study identifies 74 loci associated with educational attainment.. Nature. 533 (7604):539-42. doi: 10.1038/nature17671 PubMed PMID:27225129

Sadovnick, AD, Traboulsee, AL, Bernales, CQ, Ross, JP, Forwell, AL, Yee, IM, Guillot-Noel, L, Fontaine, B, Cournu-Rebeix, I, Alcina, A, Fedetz, M, Izquierdo, G, Matesanz, F, Hilven, K, Dubois, B, Goris, A, Astobiza, I, Alloza, I, Antigüedad, A, Vandenbroeck, K et al. (2016) Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.. G3 (Bethesda). 6 (7):2073-9. doi: 10.1534/g3.116.030841 PubMed PMID:27194806

Lill, CM, Mashychev, A, Hartmann, C, Lohmann, K, Marras, C, Lang, AE, Klein, C, Bertram, L (2016) Launching the movement disorders society genetic mutation database (MDSGene).. Mov. Disord. 31 (5):607-9. doi: 10.1002/mds.26651 PubMed PMID:27156390

Okbay, A, Baselmans, BM, De Neve, JE, Turley, P, Nivard, MG, Fontana, MA, Meddens, SF, Linnér, RK, Rietveld, CA, Derringer, J, Gratten, J, Lee, JJ, Liu, JZ, de Vlaming, R, Ahluwalia, TS, Buchwald, J, Cavadino, A, Frazier-Wood, AC, Furlotte, NA, Garfield, V et al. (2016) Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.. Nat. Genet. 48 (6):624-33. doi: 10.1038/ng.3552 PubMed PMID:27089181

Marras, C, Lang, A, van de Warrenburg, BP, Sue, CM, Tabrizi, SJ, Bertram, L, Mercimek-Mahmutoglu, S, Ebrahimi-Fakhari, D, Warner, TT, Durr, A, Assmann, B, Lohmann, K, Kostic, V, Klein, C (2016) Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force.. Mov. Disord. 31 (4):436-57. doi: 10.1002/mds.26527 PubMed PMID:27079681

Kypreou, KP, Stefanaki, I, Antonopoulou, K, Karagianni, F, Ntritsos, G, Zaras, A, Nikolaou, V, Kalfa, I, Chasapi, V, Polydorou, D, Gogas, H, Spyrou, GM, Bertram, L, Lill, CM, Ioannidis, JPA, Antoniou, C, Evangelou, E, Stratigos, AI (2016) Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score.. J. Invest. Dermatol. 136 (3):690-695. doi: 10.1016/j.jid.2015.12.007 PubMed PMID:27015455

Dubois, B, Hampel, H, Feldman, HH, Scheltens, P, Aisen, P, Andrieu, S, Bakardjian, H, Benali, H, Bertram, L, Blennow, K, Broich, K, Cavedo, E, Crutch, S, Dartigues, JF, Duyckaerts, C, Epelbaum, S, Frisoni, GB, Gauthier, S, Genthon, R, Gouw, AA et al. (2016) Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.. Alzheimers Dement. 12 (3):292-323. doi: 10.1016/j.jalz.2016.02.002 PubMed PMID:27012484

Lu, Y, Day, FR, Gustafsson, S, Buchkovich, ML, Na, J, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, ÅK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S et al. (2016) New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.. Nat Commun. 7 :10495. doi: 10.1038/ncomms10495 PubMed PMID:26833246

Lill, CM, Liu, T, Norman, K, Meyer, A, Steinhagen-Thiessen, E, Demuth, I, Bertram, L (2016) Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II).. Gerontology. 62 (3):316-22. doi: 10.1159/000438900 PubMed PMID:26821332

Gerstorf, D, Bertram, L, Lindenberger, U, Pawelec, G, Demuth, I, Steinhagen-Thiessen, E, Wagner, GG (2016) Editorial.. Gerontology. 62 (3):311-5. doi: 10.1159/000441495 PubMed PMID:26820471

Bertram, L (2016) Next Generation Sequencing in Alzheimer's Disease.. Methods Mol. Biol. 1303 :281-97. doi: 10.1007/978-1-4939-2627-5_17 PubMed PMID:26235074

Johansson, P, Bergmann, A, Rahmann, S, Wohlers, I, Scholtysik, R, Przekopowitz, M, Seifert, M, Tschurtschenthaler, G, Webersinke, G, Jäger, U, Siebert, R, Klein-Hitpass, L, Dührsen, U, Dürig, J, Küppers, R (2016) Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia.. Int. J. Cancer. 138 (1):121-4. doi: 10.1002/ijc.29697 PubMed PMID:26199174

 

2015

Kypreou, KP, Stefanaki, I, Antonopoulou, K, Karagianni, F, Ntritsos, G, Zaras, A, Nikolaou, V, Kalfa, I, Chasapi, V, Polydorou, D, Gogas, H, Spyrou, GM, Bertram, L, Lill, CM, Ioannidis, JPA, Antoniou, C, Evangelou, E, Stratigos, AI (2016) Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score.. J. Invest. Dermatol. 136 (3):690-695. doi: 10.1016/j.jid.2015.12.007 PubMed PMID:27015455

Schrewe, L, Lill, CM, Liu, T, Salmen, A, Gerdes, LA, Guillot-Noel, L, Akkad, DA, Blaschke, P, Graetz, C, Hoffjan, S, Kroner, A, Demir, S, Böhme, A, Rieckmann, P, ElAli, A, Hagemann, N, Hermann, DM, Cournu-Rebeix, I, Zipp, F, Kümpfel, T et al. (2015) Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.. J Neuroinflammation. 12 :234. doi: 10.1186/s12974-015-0429-y PubMed PMID:26669675

Dankowski, T, Buck, D, Andlauer, TF, Antony, G, Bayas, A, Bechmann, L, Berthele, A, Bettecken, T, Chan, A, Franke, A, Gold, R, Graetz, C, Haas, J, Hecker, M, Herms, S, Infante-Duarte, C, Jöckel, KH, Kieseier, BC, Knier, B, Knop, M et al. (2015) Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array.. Genet. Epidemiol. 39 (8):601-8. doi: 10.1002/gepi.21933 PubMed PMID:26497834

Lill, CM, Luessi, F, Alcina, A, Sokolova, EA, Ugidos, N, de la Hera, B, Guillot-Noël, L, Malhotra, S, Reinthaler, E, Schjeide, BM, Mescheriakova, JY, Mashychev, A, Wohlers, I, Akkad, DA, Aktas, O, Alloza, I, Antigüedad, A, Arroyo, R, Astobiza, I, Blaschke, P et al. (2015) Genome-wide significant association with seven novel multiple sclerosis risk loci.. J. Med. Genet. 52 (12):848-55. doi: 10.1136/jmedgenet-2015-103442 PubMed PMID:26475045

Moutsianas, L, Jostins, L, Beecham, AH, Dilthey, AT, Xifara, DK, Ban, M, Shah, TS, Patsopoulos, NA, Alfredsson, L, Anderson, CA, Attfield, KE, Baranzini, SE, Barrett, J, Binder, TMC, Booth, D, Buck, D, Celius, EG, Cotsapas, C, D'Alfonso, S, Dendrou, CA et al. (2015) Class II HLA interactions modulate genetic risk for multiple sclerosis.. Nat. Genet. 47 (10):1107-1113. doi: 10.1038/ng.3395 PubMed PMID:26343388

Nikpay, M, Goel, A, Won, HH, Hall, LM, Willenborg, C, Kanoni, S, Saleheen, D, Kyriakou, T, Nelson, CP, Hopewell, JC, Webb, TR, Zeng, L, Dehghan, A, Alver, M, Armasu, SM, Auro, K, Bjonnes, A, Chasman, DI, Chen, S, Ford, I et al. (2015) A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.. Nat. Genet. 47 (10):1121-1130. doi: 10.1038/ng.3396 PubMed PMID:26343387

Park, S, Lee, S, Lee, Y, Herold, C, Hooli, B, Mullin, K, Park, T, Park, C, Bertram, L, Lange, C, Tanzi, R, Won, S (2015) Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families.. BMC Med. Genet. 16 :62. doi: 10.1186/s12881-015-0198-6 PubMed PMID:26286599

Johansson, P, Bergmann, A, Rahmann, S, Wohlers, I, Scholtysik, R, Przekopowitz, M, Seifert, M, Tschurtschenthaler, G, Webersinke, G, Jäger, U, Siebert, R, Klein-Hitpass, L, Dührsen, U, Dürig, J, Küppers, R (2016) Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia.. Int. J. Cancer. 138 (1):121-4. doi: 10.1002/ijc.29697 PubMed PMID:26199174

Joshi, PK, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, AU, Schurmann, C, Smith, AV, Zhang, W, Okada, Y, Stančáková, A, Faul, JD, Zhao, W, Bartz, TM, Concas, MP, Franceschini, N, Enroth, S, Vitart, V, Trompet, S et al. (2015) Directional dominance on stature and cognition in diverse human populations.. Nature. 523 (7561):459-462. doi: 10.1038/nature14618 PubMed PMID:26131930

Lill, CM, Rengmark, A, Pihlstrøm, L, Fogh, I, Shatunov, A, Sleiman, PM, Wang, LS, Liu, T, Lassen, CF, Meissner, E, Alexopoulos, P, Calvo, A, Chio, A, Dizdar, N, Faltraco, F, Forsgren, L, Kirchheiner, J, Kurz, A, Larsen, JP, Liebsch, M et al. (2015) The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.. Alzheimers Dement. 11 (12):1407-1416. doi: 10.1016/j.jalz.2014.12.009 PubMed PMID:25936935

Lill, CM, Hansen, J, Olsen, JH, Binder, H, Ritz, B, Bertram, L (2015) Impact of Parkinson's disease risk loci on age at onset.. Mov. Disord. 30 (6):847-50. doi: 10.1002/mds.26237 PubMed PMID:25914293

Hooli, BV, Lill, CM, Mullin, K, Qiao, D, Lange, C, Bertram, L, Tanzi, RE (2015) PLD3 gene variants and Alzheimer's disease.. Nature. 520 (7545):E7-8. doi: 10.1038/nature14040 PubMed PMID:25832413

Bertram, L, Klein, C (2015) Probing the exome in Alzheimer disease and other neurodegenerative disorders.. JAMA Neurol. 72 (4):389-91. doi: 10.1001/jamaneurol.2014.4495 PubMed PMID:25706056

Hoppmann, N, Graetz, C, Paterka, M, Poisa-Beiro, L, Larochelle, C, Hasan, M, Lill, CM, Zipp, F, Siffrin, V (2015) New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.. Brain. 138 (Pt 4):902-17. doi: 10.1093/brain/awu408 PubMed PMID:25665584

Davies, G, Armstrong, N, Bis, JC, Bressler, J, Chouraki, V, Giddaluru, S, Hofer, E, Ibrahim-Verbaas, CA, Kirin, M, Lahti, J, van der Lee, SJ, Le Hellard, S, Liu, T, Marioni, RE, Oldmeadow, C, Postmus, I, Smith, AV, Smith, JA, Thalamuthu, A, Thomson, R et al. (2015) Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).. Mol. Psychiatry. 20 (2):183-92. doi: 10.1038/mp.2014.188 PubMed PMID:25644384

Lill, CM, Bertram, L (2015) Probing the epigenome by EWAS: a new era in brain disease research.. Mov. Disord. 30 (2):197. doi: 10.1002/mds.26143 PubMed PMID:25639491

Domingo, A, Westenberger, A, Lee, LV, Brænne, I, Liu, T, Vater, I, Rosales, R, Jamora, RD, Pasco, PM, Cutiongco-Dela Paz, EM, Freimann, K, Schmidt, TG, Dressler, D, Kaiser, FJ, Bertram, L, Erdmann, J, Lohmann, K, Klein, C (2015) New insights into the genetics of X-linked dystonia-parkinsonism (XDP, DYT3).. Eur. J. Hum. Genet. 23 (10):1334-40. doi: 10.1038/ejhg.2014.292 PubMed PMID:25604858

Nalls, MA, Bras, J, Hernandez, DG, Keller, MF, Majounie, E, Renton, AE, Saad, M, Jansen, I, Guerreiro, R, Lubbe, S, Plagnol, V, Gibbs, JR, Schulte, C, Pankratz, N, Sutherland, M, Bertram, L, Lill, CM, DeStefano, AL, Faroud, T, Eriksson, N et al. (2015) NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases.. Neurobiol. Aging. 36 (3):1605.e7-12. doi: 10.1016/j.neurobiolaging.2014.07.028 PubMed PMID:25444595

Antonopoulou, K, Stefanaki, I, Lill, CM, Chatzinasiou, F, Kypreou, KP, Karagianni, F, Athanasiadis, E, Spyrou, GM, Ioannidis, JPA, Bertram, L, Evangelou, E, Stratigos, AJ (2015) Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: the MelGene database.. J. Invest. Dermatol. 135 (4):1074-1079. doi: 10.1038/jid.2014.491 PubMed PMID:25407435

Wilcox, R, Brænne, I, Brüggemann, N, Winkler, S, Wiegers, K, Bertram, L, Anderson, T, Lohmann, K (2015) Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only.. J. Neurol. 262 (1):187-93. doi: 10.1007/s00415-014-7547-9 PubMed PMID:25359261

Bellander, M, Bäckman, L, Liu, T, Schjeide, BM, Bertram, L, Schmiedek, F, Lindenberger, U, Lövdén, M (2015) Lower baseline performance but greater plasticity of working memory for carriers of the val allele of the COMT Val¹⁵⁸Met polymorphism.. Neuropsychology. 29 (2):247-54. doi: 10.1037/neu0000088 PubMed PMID:24819065