Publications

Trinh, J, Lohmann, K, Baumann, H, Balck, A, Borsche, M, Brüggemann, N, Dure, L, Dean, M, Volkmann, J, Tunc, S, Prasuhn, J, Pawlack, H, Imhoff, S, Lill, CM, Kasten, M, Bauer, P, Rolfs, A, International Parkinson's Disease Genomics Consortium (IPDGC), Klein, C. (2018) Utility and implications of exome sequencing in early-onset Parkinson's disease.. Mov. Disord. :. doi: 10.1002/mds.27559

Reinthaler, EM, Graf, E, Zrzavy, T, Wieland, T, Hotzy, C, Kopecky, C, Pferschy, S, Schmied, C, Leutmezer, F, Keilani, M, Lill, CM, Hoffjan, S, Epplen, JT, Zettl, UK, Hecker, M, Deutschländer, A, Meuth, SG, Ahram, M, Mustafa, B, El-Khateeb, M et al.. (2018) TPP2 mutation associated with sterile brain inflammation mimicking MS.. Neurol Genet. 4 (6):e285. doi: 10.1212/NXG.0000000000000285

Trinh, J, Zeldenrust, FMJ, Huang, J, Kasten, M, Schaake, S, Petkovic, S, Madoev, H, Grünewald, A, Almuammar, S, König, IR, Lill, CM, Lohmann, K, Klein, C, Marras, C. (2018) Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.. Mov. Disord. :. doi: 10.1002/mds.27527

Herwest, S, Albers, C, Schmiester, M, Salewsky, B, Hopfenmüller, W, Meyer, A, Bertram, L, Demuth, I. (2018) The hSNM1B/Apollo variant rs11552449 is associated with cellular sensitivity towards mitomycin C and ionizing radiation.. DNA Repair (Amst.). 72 :93-98. doi: 10.1016/j.dnarep.2018.09.004

Ten Kate, M, Redolfi, A, Peira, E, Bos, I, Vos, SJ, Vandenberghe, R, Gabel, S, Schaeverbeke, J, Scheltens, P, Blin, O, Richardson, JC, Bordet, R, Wallin, A, Eckerstrom, C, Molinuevo, JL, Engelborghs, S, Van Broeckhoven, C, Martinez-Lage, P, Popp, J, Tsolaki, M et al.. (2018) MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study.. Alzheimers Res Ther. 10 (1):100. doi: 10.1186/s13195-018-0428-1

Wohlers, I, Bertram, L. (2018) Taking genomics research to the next level: The Genotype-Tissue expression project.. Mov. Disord. 33 (7):1097. doi: 10.1002/mds.27445

Wohlers, I, Bertram, L, Lill, CM. (2018) Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics.. J. Autoimmun. 94 :83-89. doi: 10.1016/j.jaut.2018.07.010

Ohlei, O, Dobricic, V, Lohmann, K, Klein, C, Lill, CM, Bertram, L. (2018) Field synopsis and systematic meta-analyses of genetic association studies in isolated dystonia.. Parkinsonism Relat. Disord. :. doi: 10.1016/j.parkreldis.2018.07.018

Bos, I, Vos, S, Vandenberghe, R, Scheltens, P, Engelborghs, S, Frisoni, G, Molinuevo, JL, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Baird, A, Dobson, R, Legido-Quigley, C, Sleegers, K, Van Broeckhoven, C, Bertram, L, Ten Kate, M, Barkhof, F, Zetterberg, H et al.. (2018) The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.. Alzheimers Res Ther. 10 (1):64. doi: 10.1186/s13195-018-0396-5

Davies, G, Lam, M, Harris, SE, Trampush, JW, Luciano, M, Hill, WD, Hagenaars, SP, Ritchie, SJ, Marioni, RE, Fawns-Ritchie, C, Liewald, DCM, Okely, JA, Ahola-Olli, AV, Barnes, CLK, Bertram, L, Bis, JC, Burdick, KE, Christoforou, A, DeRosse, P, Djurovic, S et al.. (2018) Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nat Commun. 9 (1):2098. doi: 10.1038/s41467-018-04362-x

Kasten, M, Hartmann, C, Hampf, J, Schaake, S, Westenberger, A, Vollstedt, EJ, Balck, A, Domingo, A, Vulinovic, F, Dulovic, M, Zorn, I, Madoev, H, Zehnle, H, Lembeck, CM, Schawe, L, Reginold, J, Huang, J, König, IR, Bertram, L, Marras, C et al.. (2018) Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review.. Mov. Disord. 33 (5):730-741. doi: 10.1002/mds.27352

Graetz, C, Gröger, A, Luessi, F, Salmen, A, Zöller, D, Schultz, J, Siller, N, Fleischer, V, Bellenberg, B, Berthele, A, Biberacher, V, Havla, J, Hecker, M, Hohlfeld, R, Infante-Duarte, C, Kirschke, JS, Kümpfel, T, Linker, R, Paul, F, Pfeuffer, S et al.. (2018) Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.. Mult. Scler. :1352458518763541. doi: 10.1177/1352458518763541

Walhovd, KB, Fjell, AM, Westerhausen, R, Nyberg, L, Ebmeier, KP, Lindenberger, U, Bartrés-Faz, D, Baaré, WFC, Siebner, HR, Henson, R, Drevon, CA, Strømstad Knudsen, GP, Ljøsne, IB, Penninx, BWJH, Ghisletta, P, Rogeberg, O, Tyler, L, Bertram, L, Lifebrain Consortium. (2018) Healthy minds 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain").. Eur. Psychiatry. 50 :47-56. doi: 10.1016/j.eurpsy.2017.12.006

Paul, KC, Schulz, J, Bronstein, JM, Lill, CM, Ritz, BR. (2018) Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.. JAMA Neurol. 75 (3):360-366. doi: 10.1001/jamaneurol.2017.4206

Walhovd, KB, Fjell, AM, Westerhausen, R, Nyberg, L, Ebmeier, KP, Lindenberger, U, Bartrés-Faz, D, Baaré, WFC, Siebner, HR, Henson, R, Drevon, CA, Knudsen, GP, Budin-Ljøsne, I, Penninx, BWJH, Ghisletta, P, Rogeberg, O, Tyler, L, Bertram, L, for Lifebrain Consortium. (2017) Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain").. Eur. Psychiatry. 47 :76-87. doi: 10.1016/j.eurpsy.2017.10.005

Zillikens, MC, Demissie, S, Hsu, YH, Yerges-Armstrong, LM, Chou, WC, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A et al.. (2017) Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.. Nat Commun. 8 (1):1414. doi: 10.1038/s41467-017-01008-2

Schuck, NW, Petok, JR, Meeter, M, Schjeide, BM, Schröder, J, Bertram, L, Gluck, MA, Li, SC. (2018) Aging and a genetic KIBRA polymorphism interactively affect feedback- and observation-based probabilistic classification learning.. Neurobiol. Aging. 61 :36-43. doi: 10.1016/j.neurobiolaging.2017.08.026

Joshi, PK, Pirastu, N, Kentistou, KA, Fischer, K, Hofer, E, Schraut, KE, Clark, DW, Nutile, T, Barnes, CLK, Timmers, PRHJ, Shen, X, Gandin, I, McDaid, AF, Hansen, TF, Gordon, SD, Giulianini, F, Boutin, TS, Abdellaoui, A, Zhao, W, Medina-Gomez, C et al.. (2017) Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.. Nat Commun. 8 (1):910. doi: 10.1038/s41467-017-00934-5

Chuang, YH, Lee, PC, Vlaar, T, Mulot, C, Loriot, MA, Hansen, J, Lill, CM, Ritz, B, Elbaz, A. (2017) Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease.. Ann. Neurol. 82 (5):655-664. doi: 10.1002/ana.25065

Buchmann, N, Scholz, M, Lill, CM, Burkhardt, R, Eckardt, R, Norman, K, Loeffler, M, Bertram, L, Thiery, J, Steinhagen-Thiessen, E, Demuth, I. (2017) Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin.. Acta Diabetol. 54 (11):1031-1038. doi: 10.1007/s00592-017-1036-4

Lill, CM, Klein, C. (2017) What would Dr. James Parkinson think today? The role of genetics in Parkinson's disease.. Mov. Disord. 32 (8):1115-1116. doi: 10.1002/mds.27141

Zillikens, MC, Demissie, S, Hsu, YH, Yerges-Armstrong, LM, Chou, WC, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A et al.. (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.. Nat Commun. 8 (1):80. doi: 10.1038/s41467-017-00031-7

Marras, C, Lang, A, van de Warrenburg, BP, Sue, CM, Tabrizi, SJ, Bertram, L, Mercimek-Mahmutoglu, S, Ebrahimi-Fakhari, D, Warner, TT, Durr, A, Assmann, B, Lohmann, K, Kostic, V, Klein, C. (2017) Nomenclature of genetic movement disorders: Recommendations of the International Parkinson and Movement Disorder Society task force.. Mov. Disord. 32 (5):724-725. doi: 10.1002/mds.27045

Lill, CM, Klein, C. (2017) [Epidemiology and causes of Parkinson's disease].. Nervenarzt. 88 (4):345-355. doi: 10.1007/s00115-017-0288-0

Chuang, YH, Lill, CM, Lee, PC, Hansen, J, Lassen, CF, Bertram, L, Greene, N, Sinsheimer, JS, Ritz, B. (2016) Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2.. Neuroepidemiology. 47 (3-4):192-200. doi: 10.1159/000450855

Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-Hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S et al.. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.. Lancet Diabetes Endocrinol. 5 (2):97-105. doi: 10.1016/S2213-8587(16)30396-5

Lill, CM. (2016) Genetics of Parkinson's disease.. Mol. Cell. Probes. 30 (6):386-396. doi: 10.1016/j.mcp.2016.11.001

Biernacka, JM, Chung, SJ, Armasu, SM, Anderson, KS, Lill, CM, Bertram, L, Ahlskog, JE, Brighina, L, Frigerio, R, Maraganore, DM. (2016) Genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease.. Parkinsonism Relat. Disord. 32 :25-30. doi: 10.1016/j.parkreldis.2016.08.002

Barban, N, Jansen, R, de Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Tragante, V, van der Laan, SW, Perry, JR, Kong, A, BIOS Consortium, Ahluwalia, TS, Albrecht, E, Yerges-Armstrong, L, Atzmon, G, Auro, K et al.. (2016) Genome-wide analysis identifies 12 loci influencing human reproductive behavior.. Nat. Genet. 48 (12):1462-1472. doi: 10.1038/ng.3698

Lee, PC, Raaschou-Nielsen, O, Lill, CM, Bertram, L, Sinsheimer, JS, Hansen, J, Ritz, B. (2016) Gene-environment interactions linking air pollution and inflammation in Parkinson's disease.. Environ. Res. 151 :713-720. doi: 10.1016/j.envres.2016.09.006

Herold, C, Hooli, BV, Mullin, K, Liu, T, Roehr, JT, Mattheisen, M, Parrado, AR, Bertram, L, Lange, C, Tanzi, RE. (2016) Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.. Mol. Psychiatry. 21 (11):1608-1612. doi: 10.1038/mp.2015.218

Klein, C, Lang, A, van de Warrenburg, BP, Sue, CM, Tabrizi, SJ, Bertram, L, Mercimek-Mahmutoglu, S, Ebrahimi-Fakhari, D, Warner, TT, Durr, A, Assmann, B, Kostic, V, Lohmann, K, Marras, C, International Parkinson and Movement Disorder Society Task Force on Classification and Nomenclature of Genetic Movement Disorders. (2016) Reply letter to Jinnah "Locus pocus" and Albanese "Complex dystonia is not a category in the new 2013 consensus classification": Necessary evolution, no magic!. Mov. Disord. 31 (11):1760-1762. doi: 10.1002/mds.26763

Andlauer, TF, Buck, D, Antony, G, Bayas, A, Bechmann, L, Berthele, A, Chan, A, Gasperi, C, Gold, R, Graetz, C, Haas, J, Hecker, M, Infante-Duarte, C, Knop, M, Kümpfel, T, Limmroth, V, Linker, RA, Loleit, V, Luessi, F, Meuth, SG et al.. (2016) Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.. Sci Adv. 2 (6):e1501678. doi: 10.1126/sciadv.1501678

Okbay, A, Beauchamp, JP, Fontana, MA, Lee, JJ, Pers, TH, Rietveld, CA, Turley, P, Chen, GB, Emilsson, V, Meddens, SF, Oskarsson, S, Pickrell, JK, Thom, K, Timshel, P, de Vlaming, R, Abdellaoui, A, Ahluwalia, TS, Bacelis, J, Baumbach, C, Bjornsdottir, G et al.. (2016) Genome-wide association study identifies 74 loci associated with educational attainment.. Nature. 533 (7604):539-42. doi: 10.1038/nature17671

Sadovnick, AD, Traboulsee, AL, Bernales, CQ, Ross, JP, Forwell, AL, Yee, IM, Guillot-Noel, L, Fontaine, B, Cournu-Rebeix, I, Alcina, A, Fedetz, M, Izquierdo, G, Matesanz, F, Hilven, K, Dubois, B, Goris, A, Astobiza, I, Alloza, I, Antigüedad, A, Vandenbroeck, K et al.. (2016) Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.. G3 (Bethesda). 6 (7):2073-9. doi: 10.1534/g3.116.030841

Lill, CM, Mashychev, A, Hartmann, C, Lohmann, K, Marras, C, Lang, AE, Klein, C, Bertram, L. (2016) Launching the movement disorders society genetic mutation database (MDSGene).. Mov. Disord. 31 (5):607-9. doi: 10.1002/mds.26651

Okbay, A, Baselmans, BM, De Neve, JE, Turley, P, Nivard, MG, Fontana, MA, Meddens, SF, Linnér, RK, Rietveld, CA, Derringer, J, Gratten, J, Lee, JJ, Liu, JZ, de Vlaming, R, Ahluwalia, TS, Buchwald, J, Cavadino, A, Frazier-Wood, AC, Furlotte, NA, Garfield, V et al.. (2016) Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.. Nat. Genet. 48 (6):624-33. doi: 10.1038/ng.3552

Marras, C, Lang, A, van de Warrenburg, BP, Sue, CM, Tabrizi, SJ, Bertram, L, Mercimek-Mahmutoglu, S, Ebrahimi-Fakhari, D, Warner, TT, Durr, A, Assmann, B, Lohmann, K, Kostic, V, Klein, C. (2016) Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force.. Mov. Disord. 31 (4):436-57. doi: 10.1002/mds.26527

Kypreou, KP, Stefanaki, I, Antonopoulou, K, Karagianni, F, Ntritsos, G, Zaras, A, Nikolaou, V, Kalfa, I, Chasapi, V, Polydorou, D, Gogas, H, Spyrou, GM, Bertram, L, Lill, CM, Ioannidis, JPA, Antoniou, C, Evangelou, E, Stratigos, AI. (2016) Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score.. J. Invest. Dermatol. 136 (3):690-695. doi: 10.1016/j.jid.2015.12.007

Dubois, B, Hampel, H, Feldman, HH, Scheltens, P, Aisen, P, Andrieu, S, Bakardjian, H, Benali, H, Bertram, L, Blennow, K, Broich, K, Cavedo, E, Crutch, S, Dartigues, JF, Duyckaerts, C, Epelbaum, S, Frisoni, GB, Gauthier, S, Genthon, R, Gouw, AA et al.. (2016) Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.. Alzheimers Dement. 12 (3):292-323. doi: 10.1016/j.jalz.2016.02.002

Lu, Y, Day, FR, Gustafsson, S, Buchkovich, ML, Na, J, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, ÅK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S et al.. (2016) New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.. Nat Commun. 7 :10495. doi: 10.1038/ncomms10495

Lill, CM, Liu, T, Norman, K, Meyer, A, Steinhagen-Thiessen, E, Demuth, I, Bertram, L. (2016) Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II).. Gerontology. 62 (3):316-22. doi: 10.1159/000438900

Gerstorf, D, Bertram, L, Lindenberger, U, Pawelec, G, Demuth, I, Steinhagen-Thiessen, E, Wagner, GG. (2016) Editorial.. Gerontology. 62 (3):311-5. doi: 10.1159/000441495

Schrewe, L, Lill, CM, Liu, T, Salmen, A, Gerdes, LA, Guillot-Noel, L, Akkad, DA, Blaschke, P, Graetz, C, Hoffjan, S, Kroner, A, Demir, S, Böhme, A, Rieckmann, P, ElAli, A, Hagemann, N, Hermann, DM, Cournu-Rebeix, I, Zipp, F, Kümpfel, T et al.. (2015) Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.. J Neuroinflammation. 12 :234. doi: 10.1186/s12974-015-0429-y

Dankowski, T, Buck, D, Andlauer, TF, Antony, G, Bayas, A, Bechmann, L, Berthele, A, Bettecken, T, Chan, A, Franke, A, Gold, R, Graetz, C, Haas, J, Hecker, M, Herms, S, Infante-Duarte, C, Jöckel, KH, Kieseier, BC, Knier, B, Knop, M et al.. (2015) Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array.. Genet. Epidemiol. 39 (8):601-8. doi: 10.1002/gepi.21933

Lill, CM, Luessi, F, Alcina, A, Sokolova, EA, Ugidos, N, de la Hera, B, Guillot-Noël, L, Malhotra, S, Reinthaler, E, Schjeide, BM, Mescheriakova, JY, Mashychev, A, Wohlers, I, Akkad, DA, Aktas, O, Alloza, I, Antigüedad, A, Arroyo, R, Astobiza, I, Blaschke, P et al.. (2015) Genome-wide significant association with seven novel multiple sclerosis risk loci.. J. Med. Genet. 52 (12):848-55. doi: 10.1136/jmedgenet-2015-103442

Moutsianas, L, Jostins, L, Beecham, AH, Dilthey, AT, Xifara, DK, Ban, M, Shah, TS, Patsopoulos, NA, Alfredsson, L, Anderson, CA, Attfield, KE, Baranzini, SE, Barrett, J, Binder, TMC, Booth, D, Buck, D, Celius, EG, Cotsapas, C, D'Alfonso, S, Dendrou, CA et al.. (2015) Class II HLA interactions modulate genetic risk for multiple sclerosis.. Nat. Genet. 47 (10):1107-1113. doi: 10.1038/ng.3395

Nikpay, M, Goel, A, Won, HH, Hall, LM, Willenborg, C, Kanoni, S, Saleheen, D, Kyriakou, T, Nelson, CP, Hopewell, JC, Webb, TR, Zeng, L, Dehghan, A, Alver, M, Armasu, SM, Auro, K, Bjonnes, A, Chasman, DI, Chen, S, Ford, I et al.. (2015) A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.. Nat. Genet. 47 (10):1121-1130. doi: 10.1038/ng.3396

Park, S, Lee, S, Lee, Y, Herold, C, Hooli, B, Mullin, K, Park, T, Park, C, Bertram, L, Lange, C, Tanzi, R, Won, S. (2015) Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families.. BMC Med. Genet. 16 :62. doi: 10.1186/s12881-015-0198-6

Bertram, L. (2016) Next Generation Sequencing in Alzheimer's Disease.. Methods Mol. Biol. 1303 :281-97. doi: 10.1007/978-1-4939-2627-5_17

2018 Inken Wohlers, Colin Schulz, Fabian Kilpert, Lars Bertram (2018) Alzheimer's disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines. bioRxiv 367318; doi: 10.1101/367318

2018 Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S Fleur W Meddens, Robbee Wedow, Mark Alan Fontana, Maël Lebreton, Abdel Abdellaoui, Anke R Hammerschlag, Michel G Nivard, Aysu Okbay, et al. (2018) Genome-wide study identifies 611 loci associated with risk tolerance and risky behaviors. bioRxiv 261081; doi: 10.1101/176511

2018 Jessica Schulz, Petros Takousis, Inken Wohlers, Ivie Itua, Valerija Dobricic, Harald Binder, Lefkos Middleton, John Ioannidis, Robert Perneczky, Lars Bertram, Christina Lill (2018) Systematic meta-analyses identify differentially expressed microRNAs in Parkinson's disease. bioRxiv 253849; doi: 10.1101/253849

2017 Gail Davies, Max Lam, Sarah E. Harris, Joey Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloë Fawns-Ritchie, David C. Liewald, Judith Okely, Ari Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, et al. (2017) Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360). bioRxiv 176511; doi: 10.1101/176511