Publications

2017

Marras C, Lang A, van de Warrenburg BP, Sue CM, Tabrizi SJ, Bertram L, Mercimek-Mahmutoglu S, Ebrahimi-Fakhari D, Warner TT, Durr A, Assmann B, Lohmann K, Kostic V, Klein C. (2017) Nomenclature of genetic movement disorders: Recommendations of the International Parkinson and Movement Disorder Society task force. Mov. Disord. 32 (5):724-725. doi: 10.1002/mds.27045

Lill CM, Klein C. (2017) [Epidemiology and causes of Parkinson's disease]. Nervenarzt. 88 (4):345-355. doi: 10.1007/s00115-017-0288-0

Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Liu T, Coassin S et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol. 5 (2):97-105. doi: 10.1016/S2213-8587(16)30396-5

2016

Chuang YH, Lill CM, Lee PC, Hansen J, Lassen CF, Bertram L, Greene N, Sinsheimer JS, Ritz B. (2016) Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2. Neuroepidemiology. 47 (3-4):192-200. doi: 10.1159/000450855

Lill CM. (2016) Genetics of Parkinson's disease. Mol. Cell. Probes. 30 (6):386-396. doi: 10.1016/j.mcp.2016.11.001

Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A, BIOS Consortium, Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K et al. (2016) Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat. Genet. 48 (12):1462-1472. doi: 10.1038/ng.3698

Lee PC, Raaschou-Nielsen O, Lill CM, Bertram L, Sinsheimer JS, Hansen J, Ritz B. (2016) Gene-environment interactions linking air pollution and inflammation in Parkinson's disease. Environ. Res. 151 :713-720. doi: 10.1016/j.envres.2016.09.006

Klein C, Lang A, van de Warrenburg BP, Sue CM, Tabrizi SJ, Bertram L, Mercimek-Mahmutoglu S, Ebrahimi-Fakhari D, Warner TT, Durr A, Assmann B, Kostic V, Lohmann K, Marras C, International Parkinson and Movement Disorder Society Task Force on Classification and Nomenclature of Genetic Movement Disorders. (2016) Reply letter to Jinnah "Locus pocus" and Albanese "Complex dystonia is not a category in the new 2013 consensus classification": Necessary evolution, no magic!. Mov. Disord. 31 (11):1760-1762. doi: 10.1002/mds.26763

Biernacka JM, Chung SJ, Armasu SM, Anderson KS, Lill CM, Bertram L, Ahlskog JE, Brighina L, Frigerio R, Maraganore DM. (2016) Genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease. Parkinsonism Relat. Disord. 32 :25-30. doi: 10.1016/j.parkreldis.2016.08.002

Andlauer TF, Buck D, Antony G, Bayas A, Bechmann L, Berthele A, Chan A, Gasperi C, Gold R, Graetz C, Haas J, Hecker M, Infante-Duarte C, Knop M, Kümpfel T, Limmroth V, Linker RA, Loleit V, Luessi F, Meuth SG et al. (2016) Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. Sci Adv. 2 (6):e1501678. doi: 10.1126/sciadv.1501678

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SF, Oskarsson S, Pickrell JK, Thom K, Timshel P, de Vlaming R, Abdellaoui A, Ahluwalia TS, Bacelis J, Baumbach C, Bjornsdottir G et al. (2016) Genome-wide association study identifies 74 loci associated with educational attainment. Nature. 533 (7604):539-42. doi: 10.1038/nature17671

Sadovnick AD, Traboulsee AL, Bernales CQ, Ross JP, Forwell AL, Yee IM, Guillot-Noel L, Fontaine B, Cournu-Rebeix I, Alcina A, Fedetz M, Izquierdo G, Matesanz F, Hilven K, Dubois B, Goris A, Astobiza I, Alloza I, Antigüedad A, Vandenbroeck K et al. (2016) Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients. G3 (Bethesda). 6 (7):2073-9. doi: 10.1534/g3.116.030841

Lill CM, Mashychev A, Hartmann C, Lohmann K, Marras C, Lang AE, Klein C, Bertram L. (2016) Launching the movement disorders society genetic mutation database (MDSGene). Mov. Disord. 31 (5):607-9. doi: 10.1002/mds.26651

Okbay A, Baselmans BM, De Neve JE, Turley P, Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J, Gratten J, Lee JJ, Liu JZ, de Vlaming R, Ahluwalia TS, Buchwald J, Cavadino A, Frazier-Wood AC, Furlotte NA, Garfield V et al. (2016) Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat. Genet. 48 (6):624-33. doi: 10.1038/ng.3552

Marras C, Lang A, van de Warrenburg BP, Sue CM, Tabrizi SJ, Bertram L, Mercimek-Mahmutoglu S, Ebrahimi-Fakhari D, Warner TT, Durr A, Assmann B, Lohmann K, Kostic V, Klein C. (2016) Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force. Mov. Disord. 31 (4):436-57. doi: 10.1002/mds.26527

Kypreou KP, Stefanaki I, Antonopoulou K, Karagianni F, Ntritsos G, Zaras A, Nikolaou V, Kalfa I, Chasapi V, Polydorou D, Gogas H, Spyrou GM, Bertram L, Lill CM, Ioannidis JP, Antoniou C, Evangelou E, Stratigos AI. (2016) Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score. J. Invest. Dermatol. 136 (3):690-5. doi: 10.1016/j.jid.2015.12.007

Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA et al. (2016) Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 12 (3):292-323. doi: 10.1016/j.jalz.2016.02.002

Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, Haring R, Hysi PG, Iles MM, Justice AE, Kanoni S et al. (2016) New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun. 7 :10495. doi: 10.1038/ncomms10495

Herold C, Hooli BV, Mullin K, Liu T, Roehr JT, Mattheisen M, Parrado AR, Bertram L, Lange C, Tanzi RE. (2016) Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. Mol. Psychiatry. 21 (11):1608-1612. doi: 10.1038/mp.2015.218

Lill CM, Liu T, Norman K, Meyer A, Steinhagen-Thiessen E, Demuth I, Bertram L. (2016) Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II). Gerontology. 62 (3):316-22. doi: 10.1159/000438900

Gerstorf D, Bertram L, Lindenberger U, Pawelec G, Demuth I, Steinhagen-Thiessen E, Wagner GG. (2016) Editorial. Gerontology. 62 (3):311-5. doi: 10.1159/000441495

Bertram L. (2016) Next Generation Sequencing in Alzheimer's Disease. Methods Mol. Biol. 1303 :281-97. doi: 10.1007/978-1-4939-2627-5_17

Johansson P, Bergmann A, Rahmann S, Wohlers I, Scholtysik R, Przekopowitz M, Seifert M, Tschurtschenthaler G, Webersinke G, Jäger U, Siebert R, Klein-Hitpass L, Dührsen U, Dürig J, Küppers R. (2016) Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. Int. J. Cancer. 138 (1):121-4. doi: 10.1002/ijc.29697

2015

Schrewe L, Lill CM, Liu T, Salmen A, Gerdes LA, Guillot-Noel L, Akkad DA, Blaschke P, Graetz C, Hoffjan S, Kroner A, Demir S, Böhme A, Rieckmann P, ElAli A, Hagemann N, Hermann DM, Cournu-Rebeix I, Zipp F, Kümpfel T et al. (2015) Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS. J Neuroinflammation. 12 :234. doi: 10.1186/s12974-015-0429-y

Dankowski T, Buck D, Andlauer TF, Antony G, Bayas A, Bechmann L, Berthele A, Bettecken T, Chan A, Franke A, Gold R, Graetz C, Haas J, Hecker M, Herms S, Infante-Duarte C, Jöckel KH, Kieseier BC, Knier B, Knop M et al. (2015) Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array. Genet. Epidemiol. 39 (8):601-8. doi: 10.1002/gepi.21933

Lill CM, Luessi F, Alcina A, Sokolova EA, Ugidos N, de la Hera B, Guillot-Noël L, Malhotra S, Reinthaler E, Schjeide BM, Mescheriakova JY, Mashychev A, Wohlers I, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Astobiza I, Blaschke P et al. (2015) Genome-wide significant association with seven novel multiple sclerosis risk loci. J. Med. Genet. 52 (12):848-55. doi: 10.1136/jmedgenet-2015-103442

Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TM, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA et al. (2015) Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat. Genet. 47 (10):1107-13. doi: 10.1038/ng.3395

Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I et al. (2015) A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47 (10):1121-30. doi: 10.1038/ng.3396

Park S, Lee S, Lee Y, Herold C, Hooli B, Mullin K, Park T, Park C, Bertram L, Lange C, Tanzi R, Won S. (2015) Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families. BMC Med. Genet. 16 :62. doi: 10.1186/s12881-015-0198-6

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S et al. (2015) Directional dominance on stature and cognition in diverse human populations. Nature. 523 (7561):459-62. doi: 10.1038/nature14618

Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M et al. (2015) The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement. 11 (12):1407-16. doi: 10.1016/j.jalz.2014.12.009

Lill CM, Hansen J, Olsen JH, Binder H, Ritz B, Bertram L. (2015) Impact of Parkinson's disease risk loci on age at onset. Mov. Disord. 30 (6):847-50. doi: 10.1002/mds.26237

Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. (2015) PLD3 gene variants and Alzheimer's disease. Nature. 520 (7545):E7-8. doi: 10.1038/nature14040

Bertram L, Klein C. (2015) Probing the exome in Alzheimer disease and other neurodegenerative disorders. JAMA Neurol. 72 (4):389-91. doi: 10.1001/jamaneurol.2014.4495

Hoppmann N, Graetz C, Paterka M, Poisa-Beiro L, Larochelle C, Hasan M, Lill CM, Zipp F, Siffrin V. (2015) New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis. Brain. 138 (Pt 4):902-17. doi: 10.1093/brain/awu408

Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R et al. (2015) Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol. Psychiatry. 20 (2):183-92. doi: 10.1038/mp.2014.188

Lill CM, Bertram L. (2015) Probing the epigenome by EWAS: a new era in brain disease research. Mov. Disord. 30 (2):197. doi: 10.1002/mds.26143

Domingo A, Westenberger A, Lee LV, Brænne I, Liu T, Vater I, Rosales R, Jamora RD, Pasco PM, Cutiongco-Dela Paz EM, Freimann K, Schmidt TG, Dressler D, Kaiser FJ, Bertram L, Erdmann J, Lohmann K, Klein C. (2015) New insights into the genetics of X-linked dystonia-parkinsonism (XDP, DYT3). Eur. J. Hum. Genet. 23 (10):1334-40. doi: 10.1038/ejhg.2014.292

Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, Plagnol V, Gibbs JR, Schulte C, Pankratz N, Sutherland M, Bertram L, Lill CM, DeStefano AL, Faroud T, Eriksson N et al. (2015) NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiol. Aging. 36 (3):1605.e7-12. doi: 10.1016/j.neurobiolaging.2014.07.028

Antonopoulou K, Stefanaki I, Lill CM, Chatzinasiou F, Kypreou KP, Karagianni F, Athanasiadis E, Spyrou GM, Ioannidis JP, Bertram L, Evangelou E, Stratigos AJ. (2015) Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: the MelGene database. J. Invest. Dermatol. 135 (4):1074-9. doi: 10.1038/jid.2014.491

Wilcox R, Brænne I, Brüggemann N, Winkler S, Wiegers K, Bertram L, Anderson T, Lohmann K. (2015) Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only. J. Neurol. 262 (1):187-93. doi: 10.1007/s00415-014-7547-9

Bellander M, Bäckman L, Liu T, Schjeide BM, Bertram L, Schmiedek F, Lindenberger U, Lövdén M. (2015) Lower baseline performance but greater plasticity of working memory for carriers of the val allele of the COMT Val¹⁵⁸Met polymorphism. Neuropsychology. 29 (2):247-54. doi: 10.1037/neu0000088

Andonov R, Djidjev H, Klau GW, Le Boudic-Jamin M, Wohlers I. (2015) Automatic classification of protein structure using the maximum contact map overlap metric. Algorithms, special issue Algorithmic Themes in Bioinformatics. 8(4):850-869. doi: 10.3390/a8040850

2014

Ahmed I, Lee PC, Lill CM, Searles Nielsen S, Artaud F, Gallagher LG, Loriot MA, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H et al. (2014) Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. PLoS Genet. 10 (11):e1004788. doi: 10.1371/journal.pgen.1004788

Athanasiadis EI, Antonopoulou K, Chatzinasiou F, Lill CM, Bourdakou MM, Sakellariou A, Kypreou K, Stefanaki I, Evangelou E, Ioannidis JP, Bertram L, Stratigos AJ, Spyrou GM. (2014) A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools. Database (Oxford). 2014. doi: 10.1093/database/bau101

Liu T, Li SC, Papenberg G, Schröder J, Roehr JT, Nietfeld W, Lindenberger U, Bertram L. (2014) No association between CTNNBL1 and episodic memory performance. Transl Psychiatry. 4 :e454. doi: 10.1038/tp.2014.93

Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE. (2014) The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 83 (15):1353-8. doi: 10.1212/WNL.0000000000000855

Lill CM. (2014) Recent advances and future challenges in the genetics of multiple sclerosis. Front Neurol. 5 :130. doi: 10.3389/fneur.2014.00130

Schröder J, Ansaloni S, Schilling M, Liu T, Radke J, Jaedicke M, Schjeide BM, Mashychev A, Tegeler C, Radbruch H, Papenberg G, Düzel S, Demuth I, Bucholtz N, Lindenberger U, Li SC, Steinhagen-Thiessen E, Lill CM, Bertram L. (2014) MicroRNA-138 is a potential regulator of memory performance in humans. Front Hum Neurosci. 8 :501. doi: 10.3389/fnhum.2014.00501

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat. Genet. 46 (9):989-93. doi: 10.1038/ng.3043

Ghisletta P, Bäckman L, Bertram L, Brandmaier AM, Gerstorf D, Liu T, Lindenberger U. (2014) The Val/Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene predicts decline in perceptual speed in older adults. Psychol Aging. 29 (2):384-92. doi: 10.1037/a0035201

Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A et al. (2014) Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis. Neurogenetics. 15 (2):129-34. doi: 10.1007/s10048-014-0396-y

Pietsch T, Wohlers I, Goschzik T, Dreschmann V, Denkhaus D, Dörner E, Rahmann S, Klein-Hitpass L. (2014) Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway. Acta Neuropathol. 127 (4):609-11. doi: 10.1007/s00401-014-1264-4

Papenberg G, Li SC, Nagel IE, Nietfeld W, Schjeide BM, Schröder J, Bertram L, Heekeren HR, Lindenberger U, Bäckman L. (2014) Dopamine and glutamate receptor genes interactively influence episodic memory in old age. Neurobiol. Aging. 35 (5):1213.e3-8. doi: 10.1016/j.neurobiolaging.2013.11.014

Hampel H, Lista S, Teipel SJ, Garaci F, Nisticò R, Blennow K, Zetterberg H, Bertram L, Duyckaerts C, Bakardjian H, Drzezga A, Colliot O, Epelbaum S, Broich K, Lehéricy S, Brice A, Khachaturian ZS, Aisen PS, Dubois B. (2014) Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020. Biochem. Pharmacol. 88 (4):426-49. doi: 10.1016/j.bcp.2013.11.009

Shen L, Thompson PM, Potkin SG, Bertram L, Farrer LA, Foroud TM, Green RC, Hu X, Huentelman MJ, Kim S, Kauwe JS, Li Q, Liu E, Macciardi F, Moore JH, Munsie L, Nho K, Ramanan VK, Risacher SL, Stone DJ et al. (2014) Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav. 8 (2):183-207. doi: 10.1007/s11682-013-9262-z

Papenberg G, Bäckman L, Nagel IE, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U, Li SC. (2014) COMT polymorphism and memory dedifferentiation in old age. Psychol Aging. 29 (2):374-83. doi: 10.1037/a0033225

Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. (2014) Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol. Psychiatry. 19 (6):676-81. doi: 10.1038/mp.2013.77

Bertram L, Böckenhoff A, Demuth I, Düzel S, Eckardt R, Li SC, Lindenberger U, Pawelec G, Siedler T, Wagner GG, Steinhagen-Thiessen E. (2014) Cohort profile: The Berlin Aging Study II (BASE-II). Int J Epidemiol. 43 (3):703-12. doi: 10.1093/ije/dyt018

Wohlers I, Le Boudic-Jamin M, Djidjev H, Klau GW, Andonov R. (2014) Exact protein structure classification using the maximum contact map overlap metric. Algorithms for Computational Biology (AlCoB). 262-273. doi: 10.3390/a8040850

2013

El-Kebir M, Marschall T, Wohlers I, Patterson M, Heringa J, Schönhuth A, Klau GW. (2013) Mapping proteins in the presence of paralogs using units of coevolution. BMC Bioinformatics. 14 Suppl 15 :S18. doi: 10.1186/1471-2105-14-S15-S18

Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM et al. (2013) Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 504 (7480):432-6. doi: 10.1038/nature12722

Bertram L, Parrado AR, Tanzi RE. (2013) TREM2 and neurodegenerative disease. N. Engl. J. Med. 369 (16):1565. doi: 10.1056/NEJMc1306509#SA2

International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B et al. (2013) Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 45 (11):1353-60. doi: 10.1038/ng.2770

Schuck NW, Frensch PA, Schjeide BM, Schröder J, Bertram L, Li SC. (2013) Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning. Neuropsychologia. 51 (13):2757-69. doi: 10.1016/j.neuropsychologia.2013.09.009

Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. (2013) Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J. Alzheimers Dis. 37 (1):217-32. doi: 10.3233/JAD-130104

Pichler I, Del Greco M F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH, PD GWAS Consortium, Nalls M, Keller MF, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield JB, Genetics of Iron Status Consortium, Pramstaller PP, Hicks AA, Thompson JR et al. (2013) Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. PLoS Med. 10 (6):e1001462. doi: 10.1371/journal.pmed.1001462

International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M et al. (2013) MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain. 136 (Pt 6):1778-82. doi: 10.1093/brain/awt101

Schuck NW, Doeller CF, Schjeide BM, Schröder J, Frensch PA, Bertram L, Li SC. (2013) Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task. Hippocampus. 23 (10):919-30. doi: 10.1002/hipo.22148

Wohlers I, Andonov R, Klau GW. (2013) DALIX: optimal DALI protein structure alignment. IEEE/ACM Trans Comput Biol Bioinform. 10 (1):26-36. doi: 10.1109/TCBB.2012.143

Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. (2013) Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells. Biochemistry. 52 (22):3899-912. doi: 10.1021/bi400138p

Li SC, Passow S, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U. (2013) Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials. Neuropsychologia. 51 (8):1649-61. doi: 10.1016/j.neuropsychologia.2013.04.005

Lill CM, Günther-Kunkel K, Hoch H, Paul F, Grond-Ginsbach C, Hausser I, Zipp F. (2013) Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations. Neurology. 80 (15):1442-3. doi: 10.1212/WNL.0b013e31828c2f8e

Broer L, Lill CM, Schuur M, Amin N, Roehr JT, Bertram L, Ioannidis JP, van Duijn CM. (2013) Distinguishing true from false positives in genomic studies: p values. Eur. J. Epidemiol. 28 (2):131-8. doi: 10.1007/s10654-012-9755-x

Papenberg G, Bäckman L, Nagel IE, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U, Li SC. (2013) Dopaminergic gene polymorphisms affect long-term forgetting in old age: further support for the magnification hypothesis. J Cogn Neurosci. 25 (4):571-9. doi: 10.1162/jocn_a_00359

Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P, Gerdes LA, Kroner A, Luessi F, Cournu-Rebeix I, Hoffjan S, Winkelmann A, Touze E, Pico F, Corcia P, Otaegui D, Antigüedad A, Alcina A, Comabella M et al. (2013) Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk. J. Med. Genet. 50 (3):140-3. doi: 10.1136/jmedgenet-2012-101411

Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. (2013) Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiol. Dis. 50 :127-34. doi: 10.1016/j.nbd.2012.10.002

Li SC, Papenberg G, Nagel IE, Preuschhof C, Schröder J, Nietfeld W, Bertram L, Heekeren HR, Lindenberger U, Bäckman L. (2013) Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory. Neurobiol. Aging. 34 (1):358.e1-10. doi: 10.1016/j.neurobiolaging.2012.08.001

2012

Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon BS et al. (2012) A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. J. Med. Genet. 49 (11):721-6. doi: 10.1136/jmedgenet-2012-101155

Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S et al. (2012) Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. J. Med. Genet. 49 (9):558-62. doi: 10.1136/jmedgenet-2012-101175

Elias-Sonnenschein LS, Bertram L, Visser PJ. (2012) Relationship between genetic risk factors and markers for Alzheimer's disease pathology. Biomark Med. 6 (4):477-95. doi: 10.2217/bmm.12.56

Sobrido MJ, Cacheiro P, Carracedo A, Bertram L. (2012) Databases for neurogenetics: introduction, overview, and challenges. Hum. Mutat. 33 (9):1311-4. doi: 10.1002/humu.22164

Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon B et al. (2012) Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology. 79 (7):659-67. doi: 10.1212/WNL.0b013e318264e353

González-Pérez P, Lu Y, Chian RJ, Sapp PC, Tanzi RE, Bertram L, McKenna-Yasek D, Gao FB, Brown RH Jr. (2012) Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS. Neurobiol. Dis. 48 (3):391-8. doi: 10.1016/j.nbd.2012.06.018

Lill CM, Bertram L. (2012) Developing the "next generation" of genetic association databases for complex diseases. Hum. Mutat. 33 (9):1366-72. doi: 10.1002/humu.22149

Wohlers I, Malod-Dognin N, Andonov R, Klau GW. (2012) CSA: comprehensive comparison of pairwise protein structure alignments. Nucleic Acids Res. 40 (Web Server issue):W303-9. doi: 10.1093/nar/gks362

Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L. (2012) Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 78 (16):1250-7. doi: 10.1212/WNL.0b013e3182515972

Bertram L, Tanzi RE. (2012) The genetics of Alzheimer's disease. Prog Mol Biol Transl Sci. 107 :79-100. doi: 10.1016/B978-0-12-385883-2.00008-4

Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA. (2012) Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining. Genet. Med. 14 (7):663-9. doi: 10.1038/gim.2012.7

Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N et al. (2012) Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 8 (3):e1002548. doi: 10.1371/journal.pgen.1002548

Lill CM, Zipp F. (2012) [The genetic profile of multiple sclerosis: risk genes and the "dark matter"]. Nervenarzt. 83 (6):705-13. doi: 10.1007/s00115-011-3438-9

Won S, Lu Q, Bertram L, Tanzi RE, Lange C. (2012) On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. Hum. Hered. 73 (1):35-46. doi: 10.1159/000331219

Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK et al. (2012) Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. Neurogenetics. 13 (1):83-6. doi: 10.1007/s10048-011-0305-6

Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, von Arnim CA. (2012) Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD. Neurobiol. Aging. 33 (1):201.e9-18. doi: 10.1016/j.neurobiolaging.2010.07.017

Wohlers I, Malod-Dognin N, Andonov R, Klau GW. (2012) CSA : Comparaison [compréhensible d’alignement de paires de structures de protéines]. Proceedings of JOBIM. 201-208.

2011

Lill CM, Bertram L. (2011) Towards unveiling the genetics of neurodegenerative diseases. Semin Neurol. 31 (5):531-41. doi: 10.1055/s-0031-1299791

Hampel H, Prvulovic D, Teipel S, Jessen F, Luckhaus C, Frölich L, Riepe MW, Dodel R, Leyhe T, Bertram L, Hoffmann W, Faltraco F, German Task Force on Alzheimer's Disease (GTF-AD). (2011) The future of Alzheimer's disease: the next 10 years. Prog. Neurobiol. 95 (4):718-28. doi: 10.1016/j.pneurobio.2011.11.008

Bertram L, Hampel H. (2011) The role of genetics for biomarker development in neurodegeneration. Prog. Neurobiol. 95 (4):501-4. doi: 10.1016/j.pneurobio.2011.09.011

Haapasalo A, Viswanathan J, Kurkinen KM, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. (2011) Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation. Commun Integr Biol. 4 (4):428-32. doi: 10.4161/cib.4.4.15283

Hiltunen M, Bertram L, Saunders AJ. (2011) Genetic risk factors: their function and comorbidities in Alzheimer's disease. Int J Alzheimers Dis. 2011 :925362. doi: 10.4061/2011/925362

Lill CM, Abel O, Bertram L, Al-Chalabi A. (2011) Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases. Amyotroph Lateral Scler. 12 (4):238-49. doi: 10.3109/17482968.2011.584629

Chatzinasiou F, Lill CM, Kypreou K, Stefanaki I, Nicolaou V, Spyrou G, Evangelou E, Roehr JT, Kodela E, Katsambas A, Tsao H, Ioannidis JP, Bertram L, Stratigos AJ. (2011) Comprehensive field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma. J. Natl. Cancer Inst. 103 (16):1227-35. doi: 10.1093/jnci/djr219

Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG et al. (2011) Call for participation in the neurogenetics consortium within the Human Variome Project. Neurogenetics. 12 (3):169-73. doi: 10.1007/s10048-011-0287-4

Bertram L. (2011) Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'. Curr Neurol Neurosci Rep. 11 (3):246-53. doi: 10.1007/s11910-011-0193-z

Pfeiffer T, Bertram L, Ioannidis JP. (2011) Quantifying selective reporting and the Proteus phenomenon for multiple datasets with similar bias. PLoS ONE. 6 (3):e18362. doi: 10.1371/journal.pone.0018362

Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M. (2011) Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol. Cell. Biol. 31 (11):2326-40. doi: 10.1128/MCB.05015-11

Schjeide BM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim CA, Bertram L. (2011) The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch. Gen. Psychiatry. 68 (2):207-13. doi: 10.1001/archgenpsychiatry.2010.196

Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. (2011) Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic. 12 (3):330-48. doi: 10.1111/j.1600-0854.2010.01149.x

Mucherino A, Wohlers I, Klau GW, Andonov R. (2011) Sparsifying distance matrices for protein-protein structure alignments. Cologne-Twente Workshop on graphs and combinatorial optimization (CTW). 211-214.

Wohlers I, Andonov R, Klau GW. (2011) Algorithm engineering for optimal alignment of protein structure distance matrices. Optimization Letters. 5(3):421-433. doi: 10.1007/s11590-011-0313-3

2010

Timmermann B, Kerick M, Roehr C, Fischer A, Isau M, Boerno ST, Wunderlich A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasbi M, Bertram L, Trappe K, Werber M, Herrmann BG, Zatloukal K, Lehrach H, Schweiger MR et al. (2010) Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS ONE. 5 (12):e15661. doi: 10.1371/journal.pone.0015661

Bertram L, Lill CM, Tanzi RE. (2010) The genetics of Alzheimer disease: back to the future. Neuron. 68 (2):270-81. doi: 10.1016/j.neuron.2010.10.013

Bertram L, Heekeren H. (2010) Obesity and the brain: a possible genetic link. Alzheimers Res Ther. 2 (5):27. doi: 10.1186/alzrt51

Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C et al. (2010) The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J. Alzheimers Dis. 22 (1):247-55. doi: 10.3233/JAD-2010-100933

Wohlers I, Domingues FS, Klau GW. (2010) Towards optimal alignment of protein structure distance matrices. Bioinformatics. 26 (18):2273-80. doi: 10.1093/bioinformatics/btq420

Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JP, Bagade S, Zheng X, Dubin RA, Bertram L, Velez Edwards DR, Menon R. (2010) Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene). Public Health Genomics. 13 (7-8):514-23. doi: 10.1159/000294202

Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, Thompson PM, Stein JL, Moore JH, Farrer LA, Green RC, Bertram L, Jack CR Jr, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. (2010) Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement. 6 (3):265-73. doi: 10.1016/j.jalz.2010.03.013

Laumet G, Chouraki V, Grenier-Boley B, Legry V, Heath S, Zelenika D, Fievet N, Hannequin D, Delepine M, Pasquier F, Hanon O, Brice A, Epelbaum J, Berr C, Dartigues JF, Tzourio C, Campion D, Lathrop M, Bertram L, Amouyel P et al. (2010) Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. J. Alzheimers Dis. 20 (4):1181-8. doi: 10.3233/JAD-2010-100126

Lill CM, Schjeide BM, Roehr JT, Zauft U, Allen NC, Zipp F, McQueen MB, Kavvoura FK, Ioannidis JP, Khoury MJ, Tanzi RE, Bertram L. (2010) Correspondence to Sand et Al. "Critical reappraisal of a catechol-o-methyltransferase transversion variant in schizophrenia". Biol. Psychiatry. 67 (7):e45-8. doi: 10.1016/j.biopsych.2010.02.003

Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C. (2010) The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. Trends Genet. 26 (2):84-93. doi: 10.1016/j.tig.2009.12.004

Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M. (2010) Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation. Biochem. Soc. Trans. 38 (Pt 1):150-5. doi: 10.1042/BST0380150

Bertram L, Tanzi RE. (2010) Alzheimer disease: New light on an old CLU. Nat Rev Neurol. 6 (1):11-3. doi: 10.1038/nrneurol.2009.213

Giedraitis V, Glaser A, Sarajärvi T, Brundin R, Gunnarsson MD, Schjeide BM, Tanzi RE, Helisalmi S, Pirttilä T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M. (2010) CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid. Neurosci. Lett. 469 (2):265-7. doi: 10.1016/j.neulet.2009.12.011

Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA. (2010) The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum. Mol. Genet. 19 (3):526-34. doi: 10.1093/hmg/ddp519

Pihlajamäki M, O' Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. (2010) Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord. 24 (1):28-36. doi: 10.1097/WAD.0b013e3181a785c9

Lill CM, Bertram L. (2010) Online databases and systematic meta-analyses of genetically complex diseases. Medizinische Genetik. 22 (2):235-241. doi: 10.1007/s11825-010-0225-0

2009

Won S, Bertram L, Becker D, Tanzi RE, Lange C. (2009) Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. Stat Biosci. 1 (2):125-143. doi: 10.1007/s12561-009-9016-z

Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. (2009) Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS ONE. 4 (11):e7893. doi: 10.1371/journal.pone.0007893

Bertram L, Tanzi RE. (2009) Genome-wide association studies in Alzheimer's disease. Hum. Mol. Genet. 18 (R2):R137-45. doi: 10.1093/hmg/ddp406

Lill CM, Hoch H, Dieste FJ, Vogel HP, Zipp F, Paul F. (2009) Bilateral stroke following pituitary apoplexy. J Clin Neurosci. 16 (12):1670-3. doi: 10.1016/j.jocn.2009.03.011

Dörr J, Bitsch A, Schmailzl KJ, Chan A, von Ahsen N, Hummel M, Varon R, Lill CM, Vogel HP, Zipp F, Paul F. (2009) Severe cardiac failure in a patient with multiple sclerosis following low-dose mitoxantrone treatment. Neurology. 73 (12):991-3. doi: 10.1212/WNL.0b013e3181b878f6

Wohlers I, Stachelscheid H, Borstlap J, Zeilinger K, Gerlach JC. (2009) The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end. Stem Cell Res. 3 (2-3):88-95. doi: 10.1016/j.scr.2009.05.001

Bertram L. (2009) Alzheimer's disease genetics current status and future perspectives. Int. Rev. Neurobiol. 84 :167-84. doi: 10.1016/S0074-7742(09)00409-7

Khoury MJ, Bertram L, Boffetta P, Butterworth AS, Chanock SJ, Dolan SM, Fortier I, Garcia-Closas M, Gwinn M, Higgins JP, Janssens AC, Ostell J, Owen RP, Pagon RA, Rebbeck TR, Rothman N, Bernstein JL, Burton PR, Campbell H, Chockalingam A et al. (2009) Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am. J. Epidemiol. 170 (3):269-79. doi: 10.1093/aje/kwp119

Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C. (2009) Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur. J. Hum. Genet. 17 (12):1676-82. doi: 10.1038/ejhg.2009.85

Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. (2009) Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Mol. Cell. Neurosci. 41 (2):166-74. doi: 10.1016/j.mcn.2009.02.008

Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L. (2009) GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Arch. Neurol. 66 (2):250-4. doi: 10.1001/archneurol.2008.552

Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. (2009) N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J. Neurochem. 108 (2):350-60. doi: 10.1111/j.1471-4159.2008.05760.x

Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. (2009) Effects of ubiquilin 1 on the unfolded protein response. J. Mol. Neurosci. 38 (1):19-30. doi: 10.1007/s12031-008-9155-6

Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L. (2009) Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 10 (1):19-25. doi: 10.1007/s10048-008-0151-3

Wohlers I, Petzold L, Domingues FS, Klau GW. (2009) PAUL: protein structural alignment using integer linear programming and Lagrangian relaxation. BMC Bioinformatics. 10(S-13):0. doi: 10.1186/1471-2105-10-S13-P2

Wohlers I, Petzold L, Domingues FS, Klau GW. (2009) Aligning protein structures using distance matrices and combinatorial optimization. German Conference on Bioinformatics (GCB). 157: 33-43.

2008

Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE. (2008) No association between CALHM1 and Alzheimer's disease risk. Cell. 135 (6):993-4; author reply 994-6. doi: 10.1016/j.cell.2008.11.030

Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL et al. (2008) Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am. J. Hum. Genet. 83 (5):623-32. doi: 10.1016/j.ajhg.2008.10.008

Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH. (2008) Association of GSK3B with Alzheimer disease and frontotemporal dementia. Arch. Neurol. 65 (10):1368-74. doi: 10.1001/archneur.65.10.1368

Bertram L, Tanzi RE. (2008) Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat. Rev. Neurosci. 9 (10):768-78. doi: 10.1038/nrn2494

Kavvoura FK, McQueen MB, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JP. (2008) Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Am. J. Epidemiol. 168 (8):855-65. doi: 10.1093/aje/kwn206

Tanzi RE, Bertram L. (2008) Alzheimer's disease: The latest suspect. Nature. 454 (7205):706-8. doi: 10.1038/454706a

Bertram L. (2008) Genetic research in schizophrenia: new tools and future perspectives. Schizophr Bull. 34 (5):806-12. doi: 10.1093/schbul/sbn079

Bertram L. (2008) The genetics of Alzheimer's disease. Handb Clin Neurol. 89 :223-32. doi: 10.1016/S0072-9752(07)01221-3

Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat. Genet. 40 (7):827-34. doi: 10.1038/ng.171

2007

Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ. (2007) Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Hum. Mol. Genet. 16 (22):2703-12. doi: 10.1093/hmg/ddm224

McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. (2007) Exploring candidate gene associations with neuropsychological performance. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (8):987-91. doi: 10.1002/ajmg.b.30500

Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M. (2007) Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. J. Med. Genet. 44 (9):606-8. doi: 10.1136/jmg.2006.048470

Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. (2007) Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. J. Biol. Chem. 282 (11):7825-32. doi: 10.1074/jbc.M609168200

Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE. (2007) Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?. J. Med. Genet. 44 (1):e63. doi: 10.1136/jmg.2005.039263

Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39 (1):17-23. doi: 10.1038/ng1934

Perry RT, Wiener H, Harrell LE, Blacker D, Tanzi RE, Bertram L, Bassett SS, Go RC. (2007) Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (2):220-7. doi: 10.1002/ajmg.b.30433

Bertram L, Hsiao M, McQueen MB, Parkinson M, Mullin K, Blacker D, Tanzi RE. (2007) The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiol. Aging. 28 (1):18.e1-4. doi: 10.1016/j.neurobiolaging.2005.11.005

2006

Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. (2006) Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J. Biol. Chem. 281 (43):32240-53. doi: 10.1074/jbc.M603106200

Bertram L, Hsiao M, Lange C, Blacker D, Tanzi RE. (2006) Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am. J. Hum. Genet. 79 (1):180-3; author reply 183-4. doi: 10.1086/505032

Jiang H, Harrington D, Raby BA, Bertram L, Blacker D, Weiss ST, Lange C. (2006) Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet. Epidemiol. 30 (2):124-32. doi: 10.1002/gepi.20132

2005

Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. (2005) Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. J. Med. Genet. 42 (11):857-62. doi: 10.1136/jmg.2004.024596

Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. (2005) Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 65 (3):404-11. doi: 10.1212/01.wnl.0000171450.97464.49

Bertram L, Tanzi RE. (2005) The genetic epidemiology of neurodegenerative disease. J. Clin. Invest. 115 (6):1449-57. doi: 10.1172/JCI24761

Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. (2005) ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. Mol. Psychiatry. 10 (6):522-4. doi: 10.1038/sj.mp.4001646

Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. (2005) Family-based association between Alzheimer's disease and variants in UBQLN1. N. Engl. J. Med. 352 (9):884-94. doi: 10.1056/NEJMoa042765

Tanzi RE, Bertram L. (2005) Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell. 120 (4):545-55. doi: 10.1016/j.cell.2005.02.008

Bertram L, Tanzi RE. (2005) The ubiquilin 1 gene and Alzheimer's disease - Reply. New Engl. J. Med. 352 (26):2753.

2004

Bertram L, Tanzi RE. (2004) The current status of Alzheimer's disease genetics: what do we tell the patients?. Pharmacol. Res. 50 (4):385-96. doi: 10.1016/j.phrs.2003.11.018

Bertram L, Parkinson M, Mullin K, Menon R, Blacker D, Tanzi RE. (2004) No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. J. Med. Genet. 41 (4):286-8.

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. (2004) Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am. J. Pathol. 164 (4):1425-34.

Bertram L, Tanzi RE. (2004) Alzheimer's disease: one disorder, too many genes?. Hum. Mol. Genet. 13 Spec No 1 :R135-41. doi: 10.1093/hmg/ddh077

Bertram L, Menon R, Mullin K, Parkinson M, Bradley ML, Blacker D, Tanzi RE. (2004) PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. Neurology. 62 (2):304-6.

2003

McQueen MB, Bertram L, Rimm EB, Blacker D, Santangelo SL. (2003) A QTL genome scan of the metabolic syndrome and its component traits. BMC Genet. 4 Suppl 1 :S96. doi: 10.1186/1471-2156-4-S1-S96

Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK et al. (2003) Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum. Mol. Genet. 12 (21):2765-76. doi: 10.1093/hmg/ddg310

Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo TJ, Basset SS, Go RC, Blacker D, Tanzi RE. (2003) No association between marker D10S1423 and Alzheimer's disease. Mol. Psychiatry. 8 (6):571-3. doi: 10.1038/sj.mp.4001355

Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, Folstein MF, McInnis MG, Bassett SS, Doheny KJ, Pugh EW et al. (2003) Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum. Mol. Genet. 12 (1):23-32.

2001

Bertram L, Tanzi RE. (2001) Of replications and refutations: the status of Alzheimer's disease genetic research. Curr Neurol Neurosci Rep. 1 (5):442-50.

Bertram L, Tanzi RE. (2001) Dancing in the dark? The status of late-onset Alzheimer's disease genetics. J. Mol. Neurosci. 17 (2):127-36. doi: 10.1385/JMN:17:2:127

Bertram L, Hayward B, Lake SL, Falls K, Van Erdewegh P, Blacker D. (2001) Family-based tests of association in the presence and absence of known linkage. Genet. Epidemiol. 21 Suppl 1 :S292-7.

Tanzi RE, Bertram L. (2001) New frontiers in Alzheimer's disease genetics. Neuron. 32 (2):181-4.

Bertram L, Guénette S, Jones J, Keeney D, Mullin K, Crystal A, Basu S, Yhu S, Deng A, Rebeck GW, Hyman BT, Go R, McInnis M, Blacker D, Tanzi R. (2001) No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease. Ann. Neurol. 49 (1):114-6.

2000

Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. (2000) Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 290 (5500):2302-3. doi: 10.1126/science.290.5500.2302

Bertram L, Blacker D, Crystal A, Mullin K, Keeney D, Jones J, Basu S, Yhu S, Guénette S, McInnis M, Go R, Tanzi R. (2000) Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies. Exp. Gerontol. 35 (9-10):1353-61.

Guénette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D. (2000) Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neurosci. Lett. 296 (1):17-20.

1998

Bertram L, Busch R, Spiegl M, Lautenschlager NT, Müller U, Kurz A. (1998) Paternal age is a risk factor for Alzheimer disease in the absence of a major gene. Neurogenetics. 1 (4):277-80.

1996

Pallapies D, Muhs A, Bertram L, Rohleder G, Nagyiványi P, Peskar BA. (1996) Effects of single oral doses of lysine clonixinate and acetylsalicylic acid on platelet functions in man. Eur. J. Clin. Pharmacol. 49 (5):351-4.