The MDSGene database systematically links reported genetic mutations with movement disorder phenotypes and other demographic and clinical information. MDSGene is still under developement and was launched to the public in June 2016. The PDGene database provides a comprehensive publicly available collection of genetic association results in Parkinson’s disease (PD). PDGene currently displays results on >7 Mio genetic variants derived from the latest meta-analysis of genome-wide association studies in PD. The ALSGene database provides a comprehensive publicly available collection of genetic association results in amyotrophic lateral sclerosis (ALS). ALSGene currently displays results on ~240.000 genetic variants, including >10.000 detailed forest plots from nearly 300 genome-wide and candidate gene association studies.
logo-alzgene The AlzGene database will provide a comprehensive publicly available collection of genetic association results in Alzheimer’s disease (AD). Our group is currently in the process of upgrading the legacy database code to the new interface already available for PD and ALS (see above).
structure_alignment CMO, PAUL, MATRASX and DALIX are tools that compute protein structure-based alignments based on comparing inter-residue distances. The programs share a common solver, but implement different scoring schemes such as contact map overlap or the scorings used by the established programs MATRAS and DALI.
Standalone versions are available here. The programs can also be used via the webserver CSA, see below.
cmo_alignment CSA (Comparative Structural Alignment) is a web service for computing and comparing protein structure alignments hosted at the CWI in Amsterdam. CSA is able to compute score-optimal alignments with respect to various inter-residue distance-based scoring schemes. Currently supported scoring schemes are;

  • Contact map overlap (CMO)
  • DALI elastic similarity scoring
  • MATRAS scoring
  • PAUL scoring