Seven new risk loci for multiple sclerosis found

In a large, international collaborative effort, LIGA researchers Lill and Bertram established seven novel genetic loci as genuine Multiple Sclerosis (MS) risk loci (i.e. LOC100506457, CD28, LPP, ETS1, DLEU1, LPIN3, and IFNGR2). To this end, they undertook an association study on >21,000 MS patients and healthy controls from Europe and Russia in which they evaluated 11 loci for their role in MS susceptibility. The majority of these loci are shared across autoimmune diseases. This study was published in the  Journal of Medical Genetics..

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LIGA researchers spearhead study on TREM2 in neurodegenerative diseases

A sequence variant in the TREM2 gene (R47H) was recently proposed as a genetic risk factor for Alzheimer’s disease. In a large international effort, LIGA investigators Christina Lill and Lars Bertram coordinated the to-date largest and most conclusive genetic study on the role of TREM2 R47H in all major neurodegenerative diseases. The work was recently published in Alzheimer’s & Dementia.

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